How Useless are Reference Ranges in Preclinical Safety Studies?

Estimation of reference ranges: how many subjects are needed?

We measured Na, K, Cl, glucose, hemoglobin, erythrocytes, and hematocrit in the serum or blood from approximately 800 male and 200 female second-year medical students in an effort to define the size of an acceptable reference population. Using the data from the men and Monte Carlo simulations of 10-400 samples, each carried out 5000 times, we found that for most of the above tests, approximatel...

Useless Actions Are Useful

Planning as heuristic search is a powerful approach to solving domain independent planning problems. In recent years, various successful heuristics and planners like FF, LPG, FAST DOWNWARD or SGPLAN have been proposed in this context. However, as heuristics only estimate the distance to goal states, a general problem of heuristic search is the existence of plateaus in the search space topology ...

Are TSH normal reference ranges adequate for pregnant women?

Determination of reference ranges using medical laboratory date

In order to have reliable reference ranges and to minimize the effects of variables such as the procedure of specimen collection, geographical location, dietary habits, life style and possible errors during the performance of tests, it  is recommended that each medical laboratory establish it's own reference values. Idealy, the reference ranges Should be determined by analysis of specimens from...

Are Biosimilars Identical to the Reference Products?